Calibration of ionic and cellular cardiac electrophysiology models
نویسندگان
چکیده
منابع مشابه
Cardiac electrophysiology: normal and ischemic ionic currents and the ECG.
Basic cardiac electrophysiology is foundational to understanding normal cardiac function in terms of rate and rhythm and initiation of cardiac muscle contraction. The primary clinical tool for assessing cardiac electrical events is the electrocardiogram (ECG), which provides global and regional information on rate, rhythm, and electrical conduction as well as changes in electrical activity asso...
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The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations for all components are combined to form the composite model, a subset of parameters is tuned, often arbitrarily and by hand, until the model outpu...
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Abnormalities in repolarization and its rate dependence are known to be related to increased proarrhythmic risk. A number of repolarization-related electrophysiological properties are commonly used as preclinical biomarkers of arrhythmic risk. However, the variability and complexity of repolarization mechanisms make the use of cellular biomarkers to predict arrhythmic risk preclinically challen...
متن کاملReference descriptions of cellular electrophysiology models
UNLABELLED In recent years there has been much development of the fundamental ideas underlying mathematical model curation in regard to models of biology. While much has been achieved in the realms of systems biology and bioinformatics, little progress has been made in relation to cellular electrophysiology modeling. The primary reason for slow progress in this field is the lack of a consistent...
متن کاملComputational modeling of electrochemical coupling: A novel finite element approach towards ionic models for cardiac electrophysiology
We propose a novel, efficient finite element solution technique to simulate the electrochemical response of excitable cardiac tissue. We apply a global–local split in which the membrane potential of the electrical problem is introduced globally as a nodal degree of freedom, while the state variables of the chemical problem are treated locally as internal variables on the integration point level...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Systems Biology and Medicine
سال: 2020
ISSN: 1939-5094
DOI: 10.1002/wsbm.1482